The Mediterranean Sea is undergoing severe changes driven by increasing anthropogenic pressures. CEtaceans and Pelagic sea TUrtles (CEPTU hereafter) are among the most important charismatic species in the Mediterranean Sea, and crucial bioindicators of marine health conditions. However, there is a data deficiency for most taxa, which is mainly due to the fact that CEPTU species spend the majority of their life in remote offshore areas that are the most difficult to monitor because of their extent. With their offshore movements, they are exposed to multiple anthropogenic stressors, such as maritime traffic causing pollution, underwater noise, disturbance and marine litter exposing the species to a higher risk of entanglement, ingestion or toxicological effects. Entanglement in fishing-related gears also contributes to increased risks linked to the pressure of fishing in pelagic areas.