The project proposes a multidisciplinary approach involving different national environmental protection system (SNPA) and national health prevention system of environmental and climate risks (SNPS) structures from 5 regions (Piedmont, Emilia-Romagna, Latium, Apulia and Sicily), as well as national health, weather and air quality scientific experts, communication experts, active citizenship associations with the aim to realize the overall objective of accelerating climate change adaptation and mitigation in urban areas, with a focus on urban green areas and sustainable mobility, and to increase, at the same time, knowledge and awareness and promote a change in citizens’ lifestyles and policies associated with major direct and indirect co-benefits at all levels: citizens, policy makers, schools, SNPA and SNPS operators. Evidence-based measures will be promoted starting from the best practices of national and international plans, policies and interventions with a focus on sustainable transport and combating urban heat island (UHI) and high temperatures. A specific focus will be devoted to vulnerability factors (clinical frailty and social vulnerability) and adaptation measures associated with social equity.