GoNEXUS aims to develop a framework for designing and assessing innovative solutions for an efficient and sustainable coordinated governance of the water-energy-food-ecosystems (WEFE) nexus. Solutions will combine policy changes and soft path options with technical and infrastructure measures for a more resilient future. To achieve this objective, the project will build a powerful model toolbox and creative participatory Nexus Dialogues. The model toolbox will include forefront global/continental and river basin models, innovatively establishing a functional link between them. At global and continental scales, the toolbox will include the individual WEFE element models CAPRI (food, agri-environment), LISFLOOD-EPIC and PCR-GLOBWB (water), PRIMES and PROMETHEUS (energy), GLOBIO (environment), and GEM-E3 (macroeconomics), some of them used in EU policies. River basin models will include nested strategic WEFE management models (including behavioral modelling) and hydrological simulation models to expand the analysis of resilience at basin scale, including impacts on ecosystems. Nexus Dialogues will co- design scenarios, models, and solutions for a joint governance of the WEFE nexus. The solutions will be evaluated using the model toolbox through a set of novel nexus indicators and criteria (based on relevant SDGs metrics) to assess trade-offs between water status, and food and energy security. GoNEXUS will be applied at global and EU levels and to six river basins representing different features and WEFE challenges in Europe (Danube, Como, Jucar, Tagus-Segura) and Africa (Zambezi, Senegal). The innovative combination of models and Nexus Dialogues will provide more accurate evaluations of future scenarios, enabling knowledge sharing and brokerage, and improving WEFE nexus management. The project will also contribute to align existing EU WEFE policies, promote the reduction of institutional fragmentation, and strengthen the EU role on water diplomacy.