Global warming has exceeded 1.5°C as a result of anthropogenic fossil fuel emissions, making it clear that deep emission reductions will need to be complemented by large-scale Carbon Dioxide Removal (CDR) to meet the Paris Agreement targets. The ocean plays a central role in the global carbon cycle, storing more than 97% of the world’s dissolved inorganic carbon and having absorbed approximately 20–30% of anthropogenic CO₂ emissions over recent decades. Despite the importance of these processes, marine (m)CDR techniques remain less developed than terrestrial approaches. Among technology-based marine CDR options, Ocean Alkalinity Enhancement (OAE) has attracted particular attention in scientific, technological, and policy debates. However, significant uncertainties remain regarding its effectiveness, techno-economic feasibility, environmental impacts, and governance implications. OAeSIS aims to address these key gaps by advancing understanding of the socio-economic, governance, and impact dimensions of OAE, thereby supporting informed decision-making and future climate policy development. OAeSIS has been developed within the framework of the “Land, ocean and water for climate action” work programme and will be implemented in close alignment with related funded activities, in particular with its sister topic “Monitoring the global ocean for safe, verifiable, and sustainable marine carbon dioxide removal (mCDR)”.